PDRN (Polydeoxyribonucleotide) is a bioactive compound made from purified DNA fragments, most commonly derived from salmon sperm (or trout), used in regenerative medicine and modern skincare.

It works primarily by activating adenosine A2A receptors and providing nucleotides for cellular repair processes, promoting tissue regeneration at the cellular level.

Key benefits (supported by studies, especially for wound healing and skin applications):

• Accelerates wound healing and tissue repair
• Stimulates collagen and elastin production → firmer, more elastic skin
• Improves skin barrier function and hydration
• Reduces inflammation and supports recovery (e.g., post-procedure or damaged skin)
• Helps with anti-aging effects like smoother texture, reduced fine lines, and better elasticity
• May aid in improving circulation and reducing hyperpigmentation

It's popular in Korean skincare (topicals/serums) and injectable treatments (like Rejuran), with stronger evidence for injected forms in medical settings, while topical use shows promising but still emerging results.